Leopoldia comosa prevents metabolic disorders in rats with high-fat diet-induced obesity.
Eur J Nutr
; 58(3): 965-979, 2019 Apr.
Article
em En
| MEDLINE
| ID: mdl-29327229
ABSTRACT
PURPOSE:
Obesity is the main feature of a complex illness known as metabolic syndrome. Anti-obesogenic therapies are often associated with side effects and represent a high cost in conventional pharmacological approaches. New strategies based on natural remedies are under continuous investigation. Leopoldia comosa (L.) Parl. (L. comosa) is a spontaneous plant with diuretic, anti-inflammatory and antioxidant properties. Recently, a hypoglycemic activity mediated by inhibition of carbohydrate digestion has been identified. The aim of this study was to evaluate the effects of a diet supplemented with L. comosa extracts on a rat model of diet-induced obesity.METHODS:
Leopoldia comosa bulb extracts were obtained using a dynamic extractor. Phytochemical properties and in vitro determination of the antioxidant activity and of the inhibitory effects on lipase and pancreatic amylase were performed. Rats were fed (12 weeks) a standard diet, or a high-fat diet (HFD), or an HFD plus L. comosa (20 or 60 mg/die) extracts. The metabolic and anthropometric parameters were recorded.RESULTS:
Results indicated that L. comosa inhibited lipase and pancreatic amylase activities. In vivo data showed that the supplementation with both doses of L. comosa extracts counteracted the HFD-dependent effects. It reduced body weight, abdominal obesity and dyslipidemia, and improved glucose tolerance with a reduction of lipidic tissue hypertrophy and liver steatosis, as compared to HFD-fed rat. In liver, L. comosa reduced protein expression levels of PEPCK and G6Pase.CONCLUSION:
We suggest that L. comosa extracts prevent obesity-dependent metabolic disorders. This paves the way for their therapeutic application as a natural anti-obesity drug.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
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Fármacos Antiobesidade
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Dieta Hiperlipídica
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Asparagaceae
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Doenças Metabólicas
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Obesidade
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article