Spontaneous splenic rupture as a rare complication of G-CSF injection.
BMJ Case Rep
; 20182018 Jan 12.
Article
em En
| MEDLINE
| ID: mdl-29330272
ABSTRACT
Splenic rupture is an infrequent and underdiagnosed side effect of granylocyte colony-stimulating factor (G-CSF). We report the case of a 54-year-old woman with brain and bone metastasis in a lung adenocarcinoma who was admitted for faintness 28 days after a G-CSF injection. Abdominal CT scan confirmed the diagnosis of splenic rupture. A conservative treatment was chosen using a peritoneal cleansing during laparoscopic surgery. Clinicians should be aware of this rare toxicity as it could be severe, but easily reversible using appropriate surgical treatment. Even if prognosis remains poor for patients with lung cancer, invasive procedures could be considered in this rapidly evolving setting, especially in case of reversible adverse event.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ruptura Espontânea
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Ruptura Esplênica
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Neoplasias Ósseas
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Neoplasias Encefálicas
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Adenocarcinoma
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Fator Estimulador de Colônias de Granulócitos
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Diálise Peritoneal
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Injeções
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Neoplasias Pulmonares
Tipo de estudo:
Etiology_studies
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Prognostic_studies
Limite:
Female
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article