Anxiety and Depression Effects During Drug Provocation Test.
J Allergy Clin Immunol Pract
; 6(5): 1637-1641, 2018.
Article
em En
| MEDLINE
| ID: mdl-29339128
ABSTRACT
BACKGROUND:
Drug provocation test (DPT) represents the gold standard for the diagnosis of drug allergy. A DPT can be performed in a single-blind placebo-controlled manner. In anxiety and depressive disorders, patients need to be evaluated to understand the nature of placebo reactions.OBJECTIVE:
The aim of this study was to evaluate the psychological profile of patients with reactions to placebo during a DPT.METHODS:
We consecutively enrolled patients with suspected drug allergy undergoing a DPT preceded by the administration of the placebo. All patients underwent the Hospital Anxiety and Depression Scale (HADS), a questionnaire aimed to identify anxiety and depression, before the challenge test.RESULTS:
A total of 196 patients were enrolled into this study 8 (4%) patients resulted positive to the DPT, 60 (30.6%) demonstrated anxiety or depression based on the HADS, and 54 had at least 1 placebo reaction during drug provocation. There were statically significant correlations between the positivity of the HADS and the finding of a placebo reaction (Fisher's exact test P < .001), and between the latter and a history of severe reactions to drug (Fisher's exact test P < .001).CONCLUSIONS:
There is a significant and strong correlation between the loss of psychic equilibrium and the development of a placebo reaction during a DPT. We suggest the use the HADS or other validated questionnaire in clinical practice before a DPT to evaluate the possible psychiatric components.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ansiedade
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Testes de Provocação Brônquica
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Efeito Placebo
/
Depressão
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Hipersensibilidade a Drogas
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article