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Synthesis and Structure-Activity Relationship Study of Biliatresone, a Plant Isoflavonoid That Causes Biliary Atresia.
Estrada, Michelle A; Zhao, Xiao; Lorent, Kristin; Kriegermeier, Alyssa; Nagao, Seika A; Berritt, Simon; Wells, Rebecca G; Pack, Michael; Winkler, Jeffrey D.
Afiliação
  • Estrada MA; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
  • Zhao X; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
  • Lorent K; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
  • Kriegermeier A; Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, United States.
  • Nagao SA; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
  • Berritt S; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
  • Wells RG; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
  • Pack M; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
  • Winkler JD; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
ACS Med Chem Lett ; 9(1): 61-64, 2018 Jan 11.
Article em En | MEDLINE | ID: mdl-29348813
We report the first synthesis of the plant isoflavonoid biliatresone. The convergent synthesis has been applied to the synthesis of several analogs, which have facilitated the first structure-activity relationship study for this environmental toxin that, on ingestion, recapitulates the phenotype of biliary atresia.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Etiology_studies Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Etiology_studies Idioma: En Ano de publicação: 2018 Tipo de documento: Article