Synthesis and Structure-Activity Relationship Study of Biliatresone, a Plant Isoflavonoid That Causes Biliary Atresia.
ACS Med Chem Lett
; 9(1): 61-64, 2018 Jan 11.
Article
em En
| MEDLINE
| ID: mdl-29348813
We report the first synthesis of the plant isoflavonoid biliatresone. The convergent synthesis has been applied to the synthesis of several analogs, which have facilitated the first structure-activity relationship study for this environmental toxin that, on ingestion, recapitulates the phenotype of biliary atresia.
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Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article