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EVIR: chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens.
Squadrito, Mario Leonardo; Cianciaruso, Chiara; Hansen, Sarah K; De Palma, Michele.
Afiliação
  • Squadrito ML; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
  • Cianciaruso C; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
  • Hansen SK; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
  • De Palma M; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Nat Methods ; 15(3): 183-186, 2018 03.
Article em En | MEDLINE | ID: mdl-29355847
We describe a lentivirus-encoded chimeric receptor, termed extracellular vesicle (EV)-internalizing receptor (EVIR), which enables the selective uptake of cancer-cell-derived EVs by dendritic cells (DCs). The EVIR enhances DC presentation of EV-associated tumor antigens to CD8+ T cells primarily through MHCI recycling and cross-dressing. EVIRs should facilitate exploring the mechanisms and implications of horizontal transfer of tumor antigens to antigen-presenting cells.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Dendríticas / Neoplasias do Colo / Linfócitos T CD8-Positivos / Vesículas Extracelulares / Receptores de Antígenos Quiméricos / Antígenos de Neoplasias Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Dendríticas / Neoplasias do Colo / Linfócitos T CD8-Positivos / Vesículas Extracelulares / Receptores de Antígenos Quiméricos / Antígenos de Neoplasias Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article