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Predictors of gait speed and its change over three years in community-dwelling older people.
Pinter, Daniela; Ritchie, Stuart J; Gattringer, Thomas; Bastin, Mark E; Hernández, Maria Del C Valdés; Corley, Janie; Maniega, Susana Muñoz; Pattie, Alison; Dickie, David A; Gow, Alan J; Starr, John M; Deary, Ian J; Enzinger, Christian; Fazekas, Franz; Wardlaw, Joanna.
Afiliação
  • Pinter D; Department of Neurology, Medical University of Graz, Graz, 8036, Austria.
  • Ritchie SJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9YL, UK.
  • Gattringer T; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9YL, UK.
  • Bastin ME; Department of Neurology, Medical University of Graz, Graz, 8036, Austria.
  • Hernández MDCV; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9YL, UK.
  • Corley J; Brain Research Imaging Centre, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Maniega SM; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Pattie A; Brain Research Imaging Centre, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Dickie DA; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Gow AJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9YL, UK.
  • Starr JM; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9YL, UK.
  • Deary IJ; Brain Research Imaging Centre, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Enzinger C; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Fazekas F; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9YL, UK.
  • Wardlaw J; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9YL, UK.
Aging (Albany NY) ; 10(1): 144-153, 2018 01 20.
Article em En | MEDLINE | ID: mdl-29356686
We aimed to assess whether and how changes in brain volume and increases in white matter hyperintensity (WMH) volume over three years predict gait speed and its change independently of demographics, vascular risk factors and physical status. We analyzed 443 individuals from the Lothian Birth Cohort 1936, at mean age 73 and 76 years. Gait speed at age 76 was predicted by age, grip strength and body mass index at mean age 73, three-year brain volume decrease and WMH volume increase, explaining 26.1% of variance. Decline in gait speed to age 76 was predicted by the same five variables explaining 40.9% of variance. In both analyses, grip strength and body mass index explained the most variance. A clinically significant decline in gait speed (≥ 0.1 m/s per year) occurred in 24.4%. These individuals had more structural brain changes. Brain volume and WMH changes were independent predictors of gait dysfunction and its three-year change, but the impact of malleable physical factors such as grip strength or body mass index was greater.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Substância Branca / Velocidade de Caminhada Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Substância Branca / Velocidade de Caminhada Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article