Effect of Antenatal Steroids on Respiratory Morbidity of Late Preterm Newborns: A Randomized Controlled Trial.
J Trop Pediatr
; 64(6): 531-538, 2018 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-29365196
ABSTRACT
OBJECTIVE:
The objective of this article was to study the effect of antenatal dexamethasone on the respiratory morbidity of late preterm newborns. STUDYDESIGN:
A randomized controlled trial, conducted in Obstetrics and Gynecology Department in collaboration with Neonatology department at JIPMER, India. In total, 155 women were studied in each group. Intention to treat analysis and per protocol analysis were done.RESULTS:
Overall 31 (10%) newborns were admitted to intensive care unit. The composite respiratory morbidity (defined as respiratory distress syndrome and/or transient tachypnea of newborn) was observed in 64 (41.6%) infants in the study and 56 (36.2%) infants in the control group. On multivariable-adjusted analysis, use of steroids was not found to be associated with decrease in composite respiratory morbidity [adjusted relative risk 0.91 (95% confidence interval 0.7-1.2)].CONCLUSIONS:
Antenatal dexamethasone does not reduce the composite respiratory morbidity of babies born vaginally or by emergency cesarean to women with late preterm labor.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cuidado Pré-Natal
/
Síndrome do Desconforto Respiratório do Recém-Nascido
/
Dexametasona
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Taquipneia Transitória do Recém-Nascido
/
Glucocorticoides
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Female
/
Humans
/
Newborn
/
Pregnancy
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article