Dual regulation of decorin by androgen and Hedgehog signaling during prostate morphogenesis.
Dev Dyn
; 247(5): 679-685, 2018 05.
Article
em En
| MEDLINE
| ID: mdl-29368411
ABSTRACT
BACKGROUND:
Prostate ductal branching morphogenesis involves a complex spatiotemporal regulation of cellular proliferation and remodeling of the extracellular matrix (ECM) around the developing ducts. Decorin (Dcn) is a small leucine-rich proteoglycan known to sequester several growth factors and to act as a tumor suppressor in prostate cancer.RESULTS:
Dcn expression in the developing prostate paralleled branching morphogenesis and was dynamically regulated by androgen and Hedgehog (Hh) signaling. DCN colocalized with collagen in the periductal stroma and acellular interstitium. Exogenous DCN decreased epithelial proliferation in ex vivo organ cultures of developing prostate, whereas genetic ablation of Dcn resulted in increased epithelial proliferation in the developing prostate.CONCLUSIONS:
Dcn expression and localization in the developing prostate is consistent with a primary role in organizing collagen around the developing ducts. Regulation of Dcn expression appears to be complex, involving both androgen and Hh signaling. The growth inhibitory effect of Dcn suggests a unique linkage between a structural proteoglycan and epithelial growth regulation. This may serve to coordinate two elements of the morphogenetic process ductal growth and organization of the collagen matrix around the nascent duct. Developmental Dynamics 247679-685, 2018. © 2018 Wiley Periodicals, Inc.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Próstata
/
Transdução de Sinais
/
Decorina
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article