An intermediate cell state allows rerouting of cell fate.
J Biol Chem
; 292(46): 19133-19134, 2017 11 17.
Article
em En
| MEDLINE
| ID: mdl-29373866
ABSTRACT
Somatic cell reprogramming into pluripotent stem cells using transcriptional factors or chemical compounds has been shown to include an intermediate cell state with epithelial features. Two recent papers show that this intermediate state can be redirected to create other differentiated cell types-specifically hepatocytes and neurons-using chemical cocktails. These results shed new light on a critical intermediate in cell fate conversion with mechanistic and practical implications.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
/
Células Epiteliais
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Reprogramação Celular
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Células-Tronco Pluripotentes Induzidas
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article