Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver.

Uno, Yasuhiro; Igawa, Yoshiyuki; Tanaka, Maori; Ohura, Kayoko; Hosokawa, Masakiyo; Imai, Teruko

Uno, Yasuhiro; Igawa, Yoshiyuki; Tanaka, Maori; Ohura, Kayoko; Hosokawa, Masakiyo; Imai, Teruko.

Afiliação

Uno Y; a Shin Nippon Biomedical Laboratories, Ltd , Kainan , Japan.
Igawa Y; b Graduate School of Pharmaceutical Sciences , Kumamoto University , Kumamoto , Japan.
Tanaka M; c Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd , Shinagawa , Japan.
Ohura K; b Graduate School of Pharmaceutical Sciences , Kumamoto University , Kumamoto , Japan.
Hosokawa M; b Graduate School of Pharmaceutical Sciences , Kumamoto University , Kumamoto , Japan.
Imai T; d Laboratory of Drug Metabolism and Biopharmaceutics, Faculty of Pharmaceutical Sciences , Chiba Institute of Science , Choshi , Japan.

Xenobiotica ; 49(2): 247-255, 2019 Feb.

Article em En | MEDLINE | ID: mdl-29384423

Assuntos

Carboxilesterase/metabolismo; Fígado/metabolismo; Macaca fascicularis/metabolismo; Alelos; Animais; Carboxilesterase/genética; Feminino; Macaca fascicularis/genética; Macaca mulatta/genética; Macaca mulatta/metabolismo; Masculino; Variantes Farmacogenômicos; RNA Mensageiro/metabolismo; Análise de Sequência de RNA

Palavras-chave

Carboxylesterase; cynomolgus macaque; gene conversion; hydrolytic activity; tissue expression; transcript variant

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carboxilesterase / Fígado / Macaca fascicularis Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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