Mechanical properties of porcine brain tissue in vivo and ex vivo estimated by MR elastography.
J Biomech
; 69: 10-18, 2018 03 01.
Article
em En
| MEDLINE
| ID: mdl-29395225
ABSTRACT
The mechanical properties of brain tissue in vivo determine the response of the brain to rapid skull acceleration. These properties are thus of great interest to the developers of mathematical models of traumatic brain injury (TBI) or neurosurgical simulations. Animal models provide valuable insight that can improve TBI modeling. In this study we compare estimates of mechanical properties of the Yucatan mini-pig brain in vivo and ex vivo using magnetic resonance elastography (MRE) at multiple frequencies. MRE allows estimations of properties in soft tissue, either in vivo or ex vivo, by imaging harmonic shear wave propagation. Most direct measurements of brain mechanical properties have been performed using samples of brain tissue ex vivo. It has been observed that direct estimates of brain mechanical properties depend on the frequency and amplitude of loading, as well as the time post-mortem and condition of the sample. Using MRE in the same animals at overlapping frequencies, we observe that porcine brain tissue in vivo appears stiffer than porcine brain tissue samples ex vivo at frequencies of 100â¯Hz and 125â¯Hz, but measurements show closer agreement at lower frequencies.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Suínos
/
Encéfalo
/
Imageamento por Ressonância Magnética
/
Técnicas de Imagem por Elasticidade
/
Fenômenos Mecânicos
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article