Activation of podocyte Notch mediates early Wt1 glomerulopathy.

Asfahani, Rowan I; Tahoun, Mona M; Miller-Hodges, Eve V; Bellerby, Jack; Virasami, Alex K; Sampson, Robert D; Moulding, Dale; Sebire, Neil J; Hohenstein, Peter; Scambler, Peter J; Waters, Aoife M

Asfahani, Rowan I; Tahoun, Mona M; Miller-Hodges, Eve V; Bellerby, Jack; Virasami, Alex K; Sampson, Robert D; Moulding, Dale; Sebire, Neil J; Hohenstein, Peter; Scambler, Peter J; Waters, Aoife M.

Afiliação

Asfahani RI; Programme of Developmental Biology of Birth Defects, Great Ormond Street Institute of Child Health, University College of London, London, UK.
Tahoun MM; Programme of Developmental Biology of Birth Defects, Great Ormond Street Institute of Child Health, University College of London, London, UK; Clinical and Chemical Pathology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Miller-Hodges EV; MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland.
Bellerby J; Programme of Developmental Biology of Birth Defects, Great Ormond Street Institute of Child Health, University College of London, London, UK.
Virasami AK; Great Ormond Street Hospital NHS Foundation Trust, London, UK.
Sampson RD; Institute of Ophthalmology, University College of London, London, UK.
Moulding D; Programme of Developmental Biology of Birth Defects, Great Ormond Street Institute of Child Health, University College of London, London, UK.
Sebire NJ; Great Ormond Street Hospital NHS Foundation Trust, London, UK.
Hohenstein P; The Roslin Institute, Edinburgh, Scotland.
Scambler PJ; Programme of Developmental Biology of Birth Defects, Great Ormond Street Institute of Child Health, University College of London, London, UK.
Waters AM; Programme of Developmental Biology of Birth Defects, Great Ormond Street Institute of Child Health, University College of London, London, UK; Great Ormond Street Hospital NHS Foundation Trust, London, UK. Electronic address: aoife.waters@ucl.ac.uk.

Kidney Int ; 93(4): 903-920, 2018 04.

Article em En | MEDLINE | ID: mdl-29398135

Assuntos

Glomerulonefrite/metabolismo; Podócitos/metabolismo; Receptor Notch1/metabolismo; Proteínas Repressoras/metabolismo; Albuminúria/genética; Albuminúria/metabolismo; Animais; Apoptose; Proteínas Reguladoras de Apoptose/genética; Proteínas Reguladoras de Apoptose/metabolismo; Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética; Fatores de Transcrição Hélice-Alça-Hélice Básicos/metabolismo; Células Cultivadas; Modelos Animais de Doenças; Transição Epitelial-Mesenquimal; Fatores de Transcrição Forkhead/genética; Fatores de Transcrição Forkhead/metabolismo; Regulação da Expressão Gênica; Glomerulonefrite/genética; Glomerulonefrite/patologia; Peptídeos e Proteínas de Sinalização Intracelular; Camundongos Endogâmicos C57BL; Camundongos Knockout; Podócitos/patologia; Proteínas/genética; Proteínas/metabolismo; Receptor Notch1/genética; Proteínas Repressoras/deficiência; Proteínas Repressoras/genética; Transdução de Sinais; Transcrição Gênica; Proteínas WT1

Palavras-chave

albuminuria; focal segmental glomerulosclerosis; nephrotic syndrome; podocyte

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Podócitos / Receptor Notch1 / Glomerulonefrite Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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