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Graphene quantum dot modified glassy carbon electrode for the determination of doxorubicin hydrochloride in human plasma.
Hashemzadeh, Nastaran; Hasanzadeh, Mohammad; Shadjou, Nasrin; Eivazi-Ziaei, Jamal; Khoubnasabjafari, Maryam; Jouyban, Abolghasem.
Afiliação
  • Hashemzadeh N; Hematology-Oncology Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran.
  • Hasanzadeh M; Faculty of Pharmacy, Students' Research Committee, Tabriz University of Medical Sciences, Tabriz 51664, Iran.
  • Shadjou N; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran.
  • Eivazi-Ziaei J; Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran.
  • Khoubnasabjafari M; Department of Nanochemistry, Nano Technology Research Center and Faculty of Chemistry Urmia University, Urmia 57154, Iran.
  • Jouyban A; Hematology-Oncology Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran.
J Pharm Anal ; 6(4): 235-241, 2016 Aug.
Article em En | MEDLINE | ID: mdl-29403988
Low toxic graphene quantum dot (GQD) was synthesized by pyrolyzing citric acid in alkaline solution and characterized by ultraviolet--visible (UV-vis) spectroscopy, X-ray diffraction (XRD), atomic force microscopy (AFM), spectrofluorimetery and dynamic light scattering (DLS) techniques. GQD was used for electrode modification and electro-oxidation of doxorubicin (DOX) at low potential. A substantial decrease in the overvoltage (-0.56 V) of the DOX oxidation reaction (compared to ordinary electrodes) was observed using GQD as coating of glassy carbon electrode (GCE). Differential pulse voltammetry was used to evaluate the analytical performance of DOX in the presence of phosphate buffer solution (pH 4.0) and good limit of detection was obtained by the proposed sensor. Such ability of GQD to promote the DOX electron-transfer reaction suggests great promise for its application as an electrochemical sensor.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article