Studies on the interaction of NMDA receptor antagonist memantine with cell membranes: A mini-review.
Chem Biol Interact
; 283: 47-50, 2018 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-29407462
ABSTRACT
Memantine is an NMDA receptor antagonist clinically used for the treatment of moderate to severe Alzheimer's disease. Currently, it is the only NMDA receptor antagonist drug marketed against this disease. Despite the large number of publications regarding its clinical and therapeutic use, studies related to its mechanism of action are still inconclusive. Knowledge of drug interactions with cell membranes may lead to the development of novel drugs for neurodegenerative diseases. The present mini-review aims to give an overview of the latest findings regarding the interaction of memantine with cell membranes, specifically with that of the human erythrocyte.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Memantina
/
Membrana Celular
/
Receptores de N-Metil-D-Aspartato
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article