Epigenetic regulation of male fate commitment from an initially bipotential system.
Mol Cell Endocrinol
; 468: 19-30, 2018 06 15.
Article
em En
| MEDLINE
| ID: mdl-29410272
ABSTRACT
A fundamental goal in biology is to understand how distinct cell types containing the same genetic information arise from a single stem cell throughout development. Sex determination is a key developmental process that requires a unidirectional commitment of an initially bipotential gonad towards either the male or female fate. This makes sex determination a unique model to study cell fate commitment and differentiation in vivo. We have focused this review on the accumulating evidence that epigenetic mechanisms contribute to the bipotential state of the fetal gonad and to the regulation of chromatin accessibility during and immediately downstream of the primary sex-determining switch that establishes the male fate.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Epigênese Genética
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article