A robust and easily reproducible protocol for the determination of size and size distribution of iron sucrose using dynamic light scattering.
J Pharm Biomed Anal
; 152: 89-93, 2018 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-29414023
ABSTRACT
Iron sucrose (IS), a nanocolloidal solution used in the treatment of iron deficiency anemia, is currently under investigation for the elucidation of its critical quality attributes. Assessment of IS's size and size distribution has been recently attempted using dynamic light scattering (DLS). However, due to heterogeneous interpretation of DLS data, variable results were retrieved. The aim of this work was to establish a simple and reproducible DLS protocol to unequivocally define the size and size distribution of IS by using size distribution approximation in Number. Underlining the limitations of the commonly used DLS approximations, we identified the drug as being composed of a population of monodisperse nanoparticles of about 7â¯nm in diameter. The method here described might therefore be useful for the evaluation of quality, safety and efficacy of IS and its follow-on versions.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos Férricos
/
Difusão Dinâmica da Luz
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Ácido Glucárico
Tipo de estudo:
Guideline
/
Prognostic_studies
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article