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New Drugs, Therapeutic Strategies, and Future Direction for the Treatment of Pulmonary Arterial Hypertension.
Mercurio, Valentina; Bianco, Anna; Campi, Giacomo; Cuomo, Alessandra; Diab, Nermin; Mancini, Angela; Parrella, Paolo; Petretta, Mario; Hassoun, Paul M; Bonaduce, Domenico.
Afiliação
  • Mercurio V; Johns Hopkins University, Division of Pulmonary and Critical Care Medicine, Baltimore, MD, United States.
  • Bianco A; Federico II University, Department of Translational Medical Sciences, Naples, Italy.
  • Campi G; Federico II University, Department of Translational Medical Sciences, Naples, Italy.
  • Cuomo A; Federico II University, Department of Translational Medical Sciences, Naples, Italy.
  • Diab N; Federico II University, Department of Translational Medical Sciences, Naples, Italy.
  • Mancini A; University of Ottawa, Department of Medicine, Ottawa, ON, Canada.
  • Parrella P; Federico II University, Department of Translational Medical Sciences, Naples, Italy.
  • Petretta M; Federico II University, Department of Translational Medical Sciences, Naples, Italy.
  • Hassoun PM; Federico II University, Department of Translational Medical Sciences, Naples, Italy.
  • Bonaduce D; Johns Hopkins University, Division of Pulmonary and Critical Care Medicine, Baltimore, MD, United States.
Curr Med Chem ; 26(16): 2844-2864, 2019.
Article em En | MEDLINE | ID: mdl-29421995
ABSTRACT
Despite recent advances in Pulmonary Arterial Hypertension (PAH) treatment, this condition is still characterized by an extremely poor prognosis. In this review, we discuss the use of newly-approved drugs for PAH treatment with already known mechanisms of action (macitentan), innovative targets (riociguat and selexipag), and novel therapeutic approaches with initial up-front combination therapy. Secondly, we describe new potential signaling pathways and investigational drugs with promising role in the treatment of PAH.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Hipertensão Pulmonar Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Hipertensão Pulmonar Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article