Novel naftopidil derivatives containing methyl phenylacetate and their blocking effects on &#945;<sub>1D/1A</sub>-adrenoreceptor subtypes.

Huang, Jun-Jun; Zhang, Zhi-Han; He, Fei; Liu, Xia-Wen; Xu, Xing-Jie; Dai, Li-Jun; Liu, Qi-Meng; Yuan, Mu

Novel naftopidil derivatives containing methyl phenylacetate and their blocking effects on α_1D/1A-adrenoreceptor subtypes.

Huang, Jun-Jun; Zhang, Zhi-Han; He, Fei; Liu, Xia-Wen; Xu, Xing-Jie; Dai, Li-Jun; Liu, Qi-Meng; Yuan, Mu.

Afiliação

Huang JJ; Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangdong 511436, PR China. Electronic address: huangjunjun1985@sina.com.
Zhang ZH; Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Department of Plant Pathology, South China Agricultural University, Guangzhou 510642, PR China.
He F; Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Department of Plant Pathology, South China Agricultural University, Guangzhou 510642, PR China.
Liu XW; Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangdong 511436, PR China.
Xu XJ; Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangdong 511436, PR China.
Dai LJ; Laboratory Animal Center, Guangzhou Medical University, Guangzhou, Guangdong 511436, PR China.
Liu QM; Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangdong 511436, PR China; Laboratory Animal Center, Guangzhou Medical University, Guangzhou, Guangdong 511436, PR
Yuan M; Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangdong 511436, PR China.

Bioorg Med Chem Lett ; 28(4): 547-551, 2018 02 15.

Article em En | MEDLINE | ID: mdl-29422390

Assuntos

Antagonistas de Receptores Adrenérgicos alfa 1/farmacologia; Naftalenos/farmacologia; Fenilacetatos/farmacologia; Piperazinas/farmacologia; Vasodilatadores/farmacologia; Antagonistas de Receptores Adrenérgicos alfa 1/síntese química; Antagonistas de Receptores Adrenérgicos alfa 1/química; Animais; Aorta/efeitos dos fármacos; Masculino; Contração Muscular/efeitos dos fármacos; Naftalenos/síntese química; Naftalenos/química; Fenilacetatos/síntese química; Fenilacetatos/química; Piperazinas/síntese química; Piperazinas/química; Prazosina/análogos & derivados; Prazosina/farmacologia; Coelhos; Ratos Sprague-Dawley; Baço/efeitos dos fármacos; Estereoisomerismo; Ducto Deferente/efeitos dos fármacos; Vasodilatadores/síntese química; Vasodilatadores/química

Palavras-chave

Benign prostatic hyperplasia; Functional assays; Piperazine derivatives; α(1)-Adrenoreceptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenilacetatos / Piperazinas / Vasodilatadores / Antagonistas de Receptores Adrenérgicos alfa 1 / Naftalenos Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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