Palladium-Catalyzed Asymmetric Allylic Alkylation of 4-Substituted Isoxazolidin-5-ones: Straightforward Access to ß2,2 -Amino Acids.
Chemistry
; 24(19): 4810-4814, 2018 Apr 03.
Article
em En
| MEDLINE
| ID: mdl-29436035
ABSTRACT
We report here an unprecedented and highly enantioselective palladium-catalyzed allylic alkylation applied to 4-substituted isoxazolidin-5-ones. Ultimately, the process provides a straightforward access to ß2,2 -amino acids bearing an all-carbon quaternary stereogenic center in great yields and a high degree of enantioselectivity.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Paládio
/
Aminoácidos
/
Isoxazóis
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article