Development of Echinocandin Resistance in Candida tropicalis following Short-Term Exposure to Caspofungin for Empiric Therapy.
Antimicrob Agents Chemother
; 62(4)2018 04.
Article
em En
| MEDLINE
| ID: mdl-29437623
ABSTRACT
Isolation of two echinocandin-resistant Candida tropicalis strains from endotracheal secretions of a patient following short-term exposure to caspofungin is described. Both strains exhibited resistance to echinocandins by Etest and reference broth microdilution, showing a homozygous S645P mutation within the hot spot 1 (HS-1) region of FKS1 and belonging to a unique multilocus sequence type. Other C. tropicalis isolates collected from patients in the same intensive care unit within a 60-day period were susceptible to echinocandins and contained wild-type FKS1 sequences.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Fúngicas
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Candida tropicalis
/
Equinocandinas
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Caspofungina
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Antifúngicos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article