High CRP Levels After Critical Illness are Associated With an Increased Risk of Rehospitalization.
Shock
; 50(5): 525-529, 2018 11.
Article
em En
| MEDLINE
| ID: mdl-29438222
ABSTRACT
PURPOSE:
Chronic inflammation, even at subclinical levels, is associated with adverse long-term outcome. PATIENTS ANDMETHODS:
In this prospective, observational study, 66 critically ill patients surviving to hospital discharge were included. C-reactive protein (CRP) levels were determined at hospital discharge, 1, 2, and 6 weeks after hospital discharge. All the patients were repeatedly screened for adverse events resulting in rehospitalization or death for 1.5 years.RESULTS:
After hospital discharge, over two-thirds of the patients exhibited elevated CRP levels (>2.0âmg/L). During the first week, CRP decreased compared with hospital discharge (Pâ<â0.001) but did not change after week 1 (Pâ=â0.67). Age (Pâ=â0.24), surgical status (Pâ=â0.95), or sepsis (Pâ=â0.77) did not influence the CRP course. The latter differed between patients with (nâ=â15) and without (nâ=â51) adverse events (Pâ=â0.003). CRP levels of patients without adverse events persistently decreased after hospital discharge (Pâ=â0.03), whereas those of patients with adverse events did not (Pâ=â0.86) but rebounded early.CONCLUSIONS:
Plasma CRP levels in critically ill patients decreased during the first week after hospital discharge but remained unchanged during the subsequent 5 weeks. Over two-thirds of the patients exhibited elevated CRP levels compatible with chronic sub-clinical inflammation. Persistently elevated CRP levels after hospital discharge are associated with higher risk of rehospitalization.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteína C-Reativa
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Estado Terminal
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Inflamação
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Tempo de Internação
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article