Diversity of murine gamma genes and expression in fetal and adult T lymphocytes.
Nature
; 322(6082): 836-40, 1986.
Article
em En
| MEDLINE
| ID: mdl-2943999
ABSTRACT
The search for the genes encoding the T-cell receptor alpha and chains revealed a third gene, T gamma (ref. 1), which shares with t T alpha (refs 2-7) and T beta (refs 8-15) genes a number of structure features, including somatic rearrangement during T-cell development. T gamma gene expression appears to be unnecessary in son mature T cells and is at its greatest in fetal thymocytes encouraging speculation that T gamma has a role in T-cell development and may be involved in the recognition of polymorphic major histocompatibility complex (MHC) products during thymic education. One argument against the participation of T gamma in such a process has been its apparently limited diversity, due to the small number of gene segments available for rearrangement. We here describe the identification of additional T gamma V-gene segments and demonstrate that they can be rearranged to previously identified J- and C-gene segments and are expressed in fetal thymocytes. In addition we describe a variety of patterns of T gamma mRNA processing which may be significant for T gamma gene regulation.
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Receptores de Antígenos de Linfócitos T
/
Linfócitos T
Limite:
Animals
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article