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Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.
Park, Min Ju; Shen, Hailian; Spaeth, Jason M; Tolvanen, Jaana H; Failor, Courtney; Knudtson, Jennifer F; McLaughlin, Jessica; Halder, Sunil K; Yang, Qiwei; Bulun, Serdar E; Al-Hendy, Ayman; Schenken, Robert S; Aaltonen, Lauri A; Boyer, Thomas G.
Afiliação
  • Park MJ; Departments of Molecular Medicine, San Antonio, Texas 78229.
  • Shen H; Departments of Molecular Medicine, San Antonio, Texas 78229.
  • Spaeth JM; Departments of Molecular Medicine, San Antonio, Texas 78229.
  • Tolvanen JH; Genome-Scale Biology Program and Department of Medical Genetics, Haartman Institute, University of Helsinki, Biomedicum, P.O. Box 63 (Haartmaninkatu 8), Helsinki FIN-00014, Finland.
  • Failor C; Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229.
  • Knudtson JF; Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229.
  • McLaughlin J; Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229.
  • Halder SK; Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia 30912.
  • Yang Q; Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia 30912.
  • Bulun SE; Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
  • Al-Hendy A; Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia 30912.
  • Schenken RS; Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229.
  • Aaltonen LA; Genome-Scale Biology Program and Department of Medical Genetics, Haartman Institute, University of Helsinki, Biomedicum, P.O. Box 63 (Haartmaninkatu 8), Helsinki FIN-00014, Finland.
  • Boyer TG; Departments of Molecular Medicine, San Antonio, Texas 78229. Electronic address: boyer@uthscsa.edu.
J Biol Chem ; 293(13): 4870-4882, 2018 03 30.
Article em En | MEDLINE | ID: mdl-29440396
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Éxons / Quinases Ciclina-Dependentes / Complexo Mediador / Ciclina C / Quinase 8 Dependente de Ciclina / Leiomioma / Mutação / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Éxons / Quinases Ciclina-Dependentes / Complexo Mediador / Ciclina C / Quinase 8 Dependente de Ciclina / Leiomioma / Mutação / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article