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Value of 18F-FET PET in adult brainstem glioma.
Albatly, Abdulrahman Abdullah; Alsamarah, Adnan Taleb; Alhawas, Abdulrahman; Veit-Haibach, Patrick; Buck, Alfred; Stolzmann, Paul; Burger, Irene A; Kollias, Spyros S; Huellner, Martin W.
Afiliação
  • Albatly AA; Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland; Department of Diagnostic Radiology, Prince Sultan Medical Military City, Makkah Road, Riyadh, Saudi Arabia.
  • Alsamarah AT; Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland; Department of Neuroradiology, University Hospital Zurich/University of Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland; Department of Diagnostic Radiology, King Fahd U
  • Alhawas A; Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland; Department of Radiology and Medical Imaging, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Electronic address: aalhawas1@ksu.edu.sa.
  • Veit-Haibach P; Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland. Electronic address: patrick.veit-haibach@usz.ch.
  • Buck A; Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland. Electronic address: fred.buck@usz.ch.
  • Stolzmann P; Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland. Electronic address: paul.stolzmann@usz.ch.
  • Burger IA; Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland. Electronic address: irene.burger@usz.ch.
  • Kollias SS; Department of Neuroradiology, University Hospital Zurich/University of Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland. Electronic address: spyros.kollias@usz.ch.
  • Huellner MW; Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland; Department of Neuroradiology, University Hospital Zurich/University of Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland. Electronic address: martin.huellner@usz.ch.
Clin Imaging ; 51: 68-75, 2018.
Article em En | MEDLINE | ID: mdl-29448122
ABSTRACT

PURPOSE:

To investigate 18F-fluoro-ethyl-tyrosine positron emission tomography (FET-PET) imaging characteristics of adult brainstem glioma (BSG). MATERIALS AND

METHODS:

FET-PET imaging and progression-free survival (PFS) of 16 adult patients with BSG was analyzed (9 high-grade gliomas, 7 low-grade gliomas). SUVmax, TBR, and time activity curves of FET-PET were calculated.

RESULTS:

Progressive gliomas had higher SUVmax (3.57 ±â€¯1.47 vs. 1.60 ±â€¯0.51; p = 0.003) and TBRmax (3.00 ±â€¯1.12 vs. 1.36 ±â€¯0.33; p = 0.001) than stable gliomas. Kaplan-Meier analysis showed longer PFS of tumors with TBRmax < 2.0 compared to tumors with TBRmax > 2.0 (665 ±â€¯32 days versus 220 ±â€¯39 days; p < 0.001).

CONCLUSION:

FET-PET uptake might be associated with disease progression in adult BSG.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tirosina / Neoplasias Encefálicas / Tronco Encefálico / Tomografia por Emissão de Pósitrons / Glioma Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tirosina / Neoplasias Encefálicas / Tronco Encefálico / Tomografia por Emissão de Pósitrons / Glioma Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article