Value of 18F-FET PET in adult brainstem glioma.
Clin Imaging
; 51: 68-75, 2018.
Article
em En
| MEDLINE
| ID: mdl-29448122
ABSTRACT
PURPOSE:
To investigate 18F-fluoro-ethyl-tyrosine positron emission tomography (FET-PET) imaging characteristics of adult brainstem glioma (BSG). MATERIALS ANDMETHODS:
FET-PET imaging and progression-free survival (PFS) of 16 adult patients with BSG was analyzed (9 high-grade gliomas, 7 low-grade gliomas). SUVmax, TBR, and time activity curves of FET-PET were calculated.RESULTS:
Progressive gliomas had higher SUVmax (3.57⯱â¯1.47 vs. 1.60⯱â¯0.51; pâ¯=â¯0.003) and TBRmax (3.00⯱â¯1.12 vs. 1.36⯱â¯0.33; pâ¯=â¯0.001) than stable gliomas. Kaplan-Meier analysis showed longer PFS of tumors with TBRmaxâ¯<â¯2.0 compared to tumors with TBRmaxâ¯>â¯2.0 (665⯱â¯32â¯days versus 220⯱â¯39â¯days; pâ¯<â¯0.001).CONCLUSION:
FET-PET uptake might be associated with disease progression in adult BSG.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Tirosina
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Neoplasias Encefálicas
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Tronco Encefálico
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Tomografia por Emissão de Pósitrons
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Glioma
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article