The gene-environmental architecture of the development of adolescent substance use.
Psychol Med
; 48(15): 2500-2507, 2018 11.
Article
em En
| MEDLINE
| ID: mdl-29455677
ABSTRACT
BACKGROUND:
Using a longitudinal twin design and a latent growth curve/autoregressive approach, this study examined the genetic-environmental architecture of substance use across adolescence.METHODS:
Self-reports of substance use (i.e. alcohol, marijuana) were collected at ages 13, 14, 15, and 17 years from 476 twin pairs (475 boys, 477 girls) living in the Province of Quebec, Canada. Substance use increased linearly across the adolescent years.RESULTS:
ACE modeling revealed that genetic, as well as shared and non-shared environmental factors explained the overall level of substance use and that these same factors also partly accounted for growth in substance use from age 13 to 17. Additional genetic factors predicted the growth in substance use. Finally, autoregressive effects revealed age-specific non-shared environmental influences and, to a lesser degree, age-specific genetic influences, which together accounted for the stability of substance use across adolescence.CONCLUSIONS:
The results support and expand the notion that genetic and environmental influences on substance use during adolescence are both developmentally stable and developmentally dynamic.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Meio Social
/
Sistema de Registros
/
Abuso de Maconha
/
Comportamento do Adolescente
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Predisposição Genética para Doença
/
Desenvolvimento do Adolescente
/
Alcoolismo
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Female
/
Humans
/
Male
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article