Modular Access to Azepines by Directed Carbonylative C-C Bond Activation of Aminocyclopropanes.
J Am Chem Soc
; 140(8): 2743-2747, 2018 02 28.
Article
em En
| MEDLINE
| ID: mdl-29461050
ABSTRACT
A modular Rh-catalyzed entry to azepines is outlined. Under a CO atmosphere, protecting group directed C-C bond activation of aminocyclopropanes provides rhodacyclopentanones. These intermediates are effective for intramolecular C-H metalation of either an N-aryl or N-vinyl unit en route to azepine ring systems. Thus, byproduct-free heterocyclizations are enabled by sequential C-C activation and C-H functionalization steps.
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MEDLINE
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En
Ano de publicação:
2018
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Article