Melatonin Regulates the Synthesis of Steroid Hormones on Male Reproduction: A Review.
Molecules
; 23(2)2018 Feb 17.
Article
em En
| MEDLINE
| ID: mdl-29462985
ABSTRACT
Melatonin is a ubiquitous molecule and exhibits different effects in long-day and short-day breeding animals. Testosterone, the main resource of androgens in the testis, is produced by Leydig cells but regulated mainly by cytokine secreted by Sertoli cells. Melatonin acts as a local modulator of the endocrine activity in Leydig cells. In Sertoli cells, melatonin influences cellular proliferation and energy metabolism and, consequently, can regulate steroidogenesis. These suggest melatonin as a key player in the regulation of steroidogenesis. However, the melatonin-induced regulation of steroid hormones may differ among species, and the literature data indicate that melatonin has important effects on steroidogenesis and male reproduction.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Reprodução
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Hormônios Esteroides Gonadais
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Melatonina
Limite:
Animals
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Humans
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Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article