The interplay of histone H2B ubiquitination with budding and fission yeast heterochromatin.
Curr Genet
; 64(4): 799-806, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-29464330
ABSTRACT
Mono-ubiquitinated histone H2B (H2B-Ub) is important for chromatin regulation of transcription, chromatin assembly, and also influences heterochromatin. In this review, we discuss the effects of H2B-Ub from nucleosome to higher-order chromatin structure. We then assess what is currently known of the role of H2B-Ub in heterochromatic silencing in budding and fission yeasts (S. cerevisiae and S. pombe), which have distinct silencing mechanisms. In budding yeast, the SIR complex initiates heterochromatin assembly with the aid of a H2B-Ub deubiquitinase, Ubp10. In fission yeast, the RNAi-dependent pathway initiates heterochromatin in the context of low H2B-Ub. We examine how the different silencing machineries overcome the challenge of H2B-Ub chromatin and highlight the importance of using these microorganisms to further our understanding of H2B-Ub in heterochromatic silencing pathways.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Nucleares
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Heterocromatina
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Histonas
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Proteínas de Saccharomyces cerevisiae
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Proteínas Reguladoras de Informação Silenciosa de Saccharomyces cerevisiae
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Ubiquitina Tiolesterase
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article