Total Synthesis of (-)-Enigmazoleâ
A.
Angew Chem Int Ed Engl
; 57(18): 5143-5146, 2018 04 23.
Article
em En
| MEDLINE
| ID: mdl-29469216
ABSTRACT
Total synthesis of (-)-enigmazoleâ
A, a marine macrolide natural product with cytotoxic activity, has been accomplished. The tetrahydropyran moiety was constructed by means of a domino olefin cross-metathesis/intramolecular oxa-Michael addition of a δ-hydroxy olefin. After coupling of advanced intermediates, the macrocycle was formed through gold-catalyzed rearrangement of a propargylic benzoate, followed by ring-closing metathesis of the resultant α,ß-unsaturated ketone.
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Base de dados:
MEDLINE
Assunto principal:
Compostos Organofosforados
/
Oxazóis
/
Macrolídeos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article