Design, synthesis and biological assessment of N-adamantyl, substituted adamantyl and noradamantyl phthalimidines for nitrite, TNF-&#945; and angiogenesis inhibitory activities.

Luo, Weiming; Tweedie, David; Beedie, Shaunna L; Vargesson, Neil; Figg, William D; Greig, Nigel H; Scerba, Michael T

Design, synthesis and biological assessment of N-adamantyl, substituted adamantyl and noradamantyl phthalimidines for nitrite, TNF-α and angiogenesis inhibitory activities.

Luo, Weiming; Tweedie, David; Beedie, Shaunna L; Vargesson, Neil; Figg, William D; Greig, Nigel H; Scerba, Michael T.

Afiliação

Luo W; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Tweedie D; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Beedie SL; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK; Molecular Pharmacology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Vargesson N; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK.
Figg WD; Molecular Pharmacology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Greig NH; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address: greign@grc.nia.nih.gov.
Scerba MT; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

Bioorg Med Chem ; 26(8): 1547-1559, 2018 05 01.

Article em En | MEDLINE | ID: mdl-29472124

Assuntos

Inibidores da Angiogênese/farmacologia; Desenho de Fármacos; Fármacos Neuroprotetores/farmacologia; Nitritos/antagonistas & inibidores; Ftalimidas/farmacologia; Fator de Necrose Tumoral alfa/antagonistas & inibidores; Inibidores da Angiogênese/síntese química; Inibidores da Angiogênese/química; Animais; Sobrevivência Celular/efeitos dos fármacos; Células Cultivadas; Relação Dose-Resposta a Droga; Lipopolissacarídeos/antagonistas & inibidores; Lipopolissacarídeos/farmacologia; Camundongos; Estrutura Molecular; Fármacos Neuroprotetores/síntese química; Fármacos Neuroprotetores/química; Nitritos/metabolismo; Ftalimidas/síntese química; Ftalimidas/química; Células RAW 264.7; Relação Estrutura-Atividade; Fator de Necrose Tumoral alfa/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ftalimidas / Desenho de Fármacos / Fator de Necrose Tumoral alfa / Fármacos Neuroprotetores / Inibidores da Angiogênese / Nitritos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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