Effects of Diets with Different Proportions of Protein/Carbohydrate on Retinal Manifestations in db Mice.
In Vivo
; 32(2): 265-272, 2018.
Article
em En
| MEDLINE
| ID: mdl-29475908
ABSTRACT
BACKGROUND/AIM:
Diabetic nephropathy is aggravated by a higher intake of total protein. The effects of diets with different proportions of protein and carbohydrate on diabetic retinopathy in db mice, a type-2 diabetes animal model, were examined, as well as diabetic nephropathy. MATERIALS ANDMETHODS:
Control and db mice at 5 weeks of age were fed the diets (% energy of protein/carbohydrate/fat; L-diet 12/71/17; H-diet 24/59/17) under ad libitum conditions and pair-feeding conditions for 6 weeks, respectively.RESULTS:
Mice fed the H-diet showed significantly greater retinal thickness by optical coherence tomography, and lower mRNA levels of angiotensinogen. Comparing combinations of diets and genotypes, db-H mice showed significantly higher mRNA levels of angiotensin-converting enzyme, advanced glycosylation end product-specific receptor, and cluster of differentiation molecule 11b (a microglial marker) than db-L mice.CONCLUSION:
Dietary protein and carbohydrate proportions influenced retinal manifestations, including retinal thickness and gene expression in control and diabetic mice.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Retina
/
Carboidratos da Dieta
/
Proteínas Alimentares
/
Retinopatia Diabética
/
Dieta
/
Ração Animal
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article