Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane.

Zhang, Liang; Trushin, Sergey; Christensen, Trace A; Tripathi, Utkarsh; Hong, Courtney; Geroux, Rachel E; Howell, Kyle G; Poduslo, Joseph F; Trushina, Eugenia

Zhang, Liang; Trushin, Sergey; Christensen, Trace A; Tripathi, Utkarsh; Hong, Courtney; Geroux, Rachel E; Howell, Kyle G; Poduslo, Joseph F; Trushina, Eugenia.

Afiliação

Zhang L; Department of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA. Electronic address: Zhang.liang@mayo.edu.
Trushin S; Department of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA. Electronic address: Trushin.Sergey@mayo.edu.
Christensen TA; Microscopy and Cell Analysis Core Facility, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA. Electronic address: Christensen.Trace@mayo.edu.
Tripathi U; Department of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA. Electronic address: Tripathi.Utkarsh@mayo.edu.
Hong C; Department of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Geroux RE; Department of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA. Electronic address: Geroux.Rachel@mayo.edu.
Howell KG; Department of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA; Microscopy and Cell Analysis Core Facility, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA. Electronic address: Howell.kyle@mayo.edu.
Poduslo JF; Department of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA; Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA. Electronic address: poduslo@mayo.edu.
Trushina E; Department of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA. Electronic address: Trushina.eugenia@mayo.edu.

Neurobiol Dis ; 114: 1-16, 2018 06.

Article em En | MEDLINE | ID: mdl-29477640

Assuntos

Peptídeos beta-Amiloides/metabolismo; Axônios/metabolismo; Membrana Celular/metabolismo; Mitocôndrias/metabolismo; Agregados Proteicos/fisiologia; Sequência de Aminoácidos; Peptídeos beta-Amiloides/genética; Peptídeos beta-Amiloides/farmacologia; Animais; Axônios/efeitos dos fármacos; Axônios/patologia; Membrana Celular/efeitos dos fármacos; Membrana Celular/patologia; Células Cultivadas; Feminino; Hipocampo/efeitos dos fármacos; Hipocampo/metabolismo; Hipocampo/patologia; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/patologia; Gravidez; Agregados Proteicos/efeitos dos fármacos; Ligação Proteica/efeitos dos fármacos; Ligação Proteica/fisiologia; Transporte Proteico/efeitos dos fármacos; Transporte Proteico/fisiologia

Palavras-chave

Aggregation; Alzheimer's disease; Amyloid beta peptides; Atomic force microscopy; Axonal transport; Bioenergetics; Dynamic light scattering; Electron microscopy; Endocytosis; Fibrils; Mitochondria; Mitochondrial function; Mouse models of AD; Oligomers; Plasma membrane binding; Primary neurons; Seahorse extracellular flux analyzer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Axônios / Membrana Celular / Peptídeos beta-Amiloides / Agregados Proteicos / Mitocôndrias Limite: Animals / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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