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Pharmacophore requirements for HIV-1 reverse transcriptase inhibitors that selectively "Freeze" the pre-translocated complex during the polymerization catalytic cycle.
Lacbay, Cyrus M; Menni, Michael; Bernatchez, Jean A; Götte, Matthias; Tsantrizos, Youla S.
Afiliação
  • Lacbay CM; Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
  • Menni M; Department of Biochemistry, McGill University, 3655 Sir William Osler Promenade, Montreal, Quebec H3G1Y6, Canada.
  • Bernatchez JA; Department of Biochemistry, McGill University, 3655 Sir William Osler Promenade, Montreal, Quebec H3G1Y6, Canada.
  • Götte M; Department of Medical Microbiology and Immunology, University of Alberta, 6-020 Katz Group Centre, Edmonton, Alberta T6G 2E1, Canada; Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, Quebec H3A 2B4, Canada.
  • Tsantrizos YS; Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada; Department of Biochemistry, McGill University, 3655 Sir William Osler Promenade, Montreal, Quebec H3G1Y6, Canada. Electronic address: youla.tsantrizos@mcgill.ca.
Bioorg Med Chem ; 26(8): 1713-1726, 2018 05 01.
Article em En | MEDLINE | ID: mdl-29478802
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Difosfatos / Inibidores da Transcriptase Reversa / Transcriptase Reversa do HIV / Bibliotecas de Moléculas Pequenas Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Difosfatos / Inibidores da Transcriptase Reversa / Transcriptase Reversa do HIV / Bibliotecas de Moléculas Pequenas Idioma: En Ano de publicação: 2018 Tipo de documento: Article