Alkenylation of C(sp3 )-H Bonds by Zincation/Copper-Catalyzed Cross-Coupling with Iodonium Salts.
Angew Chem Int Ed Engl
; 57(17): 4727-4731, 2018 04 16.
Article
em En
| MEDLINE
| ID: mdl-29479782
ABSTRACT
α-Vinylation of phosphonates, phosphine oxides, sulfones, sulfonamides, and sulfoxides has been achieved by selective C-H zincation and copper-catalyzed C(sp3 )-C(sp2 ) cross-coupling reaction using vinylphenyliodonium salts. The vinylation transformation proceeds in high efficiency and stereospecificity under mild reaction conditions. This zincative cross-coupling reaction represents a general alkenylation strategy, which is also applicable for α-alkenylation of esters, amides, and nitriles in the synthesis of ß,γ-unsaturated carbonyl compounds.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Zinco
/
Cobre
/
Organofosfonatos
/
Hidrocarbonetos Iodados
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article