Synthesis and biological evaluation of N-arylpiperazine derivatives of 4,4-dimethylisoquinoline-1,3(2H,4H)-dione as potential antiplatelet agents.

Marcinkowska, Monika; Kotanska, Magdalena; Zagórska, Agnieszka; Sniecikowska, Joanna; Kubacka, Monika; Siwek, Agata; Bucki, Adam; Pawlowski, Maciej; Bednarski, Marek; Sapa, Jacek; Starek, Malgorzata; Dabrowska, Monika; Kolaczkowski, Marcin

Marcinkowska, Monika; Kotanska, Magdalena; Zagórska, Agnieszka; Sniecikowska, Joanna; Kubacka, Monika; Siwek, Agata; Bucki, Adam; Pawlowski, Maciej; Bednarski, Marek; Sapa, Jacek; Starek, Malgorzata; Dabrowska, Monika; Kolaczkowski, Marcin.

Afiliação

Marcinkowska M; a Department of Medicinal Chemistry , Jagiellonian University Medical College , Kraków , Poland.
Kotanska M; b Department of Pharmacological Screening , Chair of Pharmacodynamics, Jagiellonian University Medical College , Krakó , Poland.
Zagórska A; a Department of Medicinal Chemistry , Jagiellonian University Medical College , Kraków , Poland.
Sniecikowska J; a Department of Medicinal Chemistry , Jagiellonian University Medical College , Kraków , Poland.
Kubacka M; b Department of Pharmacological Screening , Chair of Pharmacodynamics, Jagiellonian University Medical College , Krakó , Poland.
Siwek A; c Department of Pharmacobiology , Jagiellonian University Medical College , Kraków , Poland.
Bucki A; a Department of Medicinal Chemistry , Jagiellonian University Medical College , Kraków , Poland.
Pawlowski M; a Department of Medicinal Chemistry , Jagiellonian University Medical College , Kraków , Poland.
Bednarski M; d Department of Pharmacological Screening , Chair of Pharmacodynamics, Jagiellonian University Medical College , Kraków , Poland.
Sapa J; d Department of Pharmacological Screening , Chair of Pharmacodynamics, Jagiellonian University Medical College , Kraków , Poland.
Starek M; e Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy , Jagiellonian University Medical College , Krakow , Poland.
Dabrowska M; e Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy , Jagiellonian University Medical College , Krakow , Poland.
Kolaczkowski M; a Department of Medicinal Chemistry , Jagiellonian University Medical College , Kraków , Poland.

J Enzyme Inhib Med Chem ; 33(1): 536-545, 2018 Dec.

Article em En | MEDLINE | ID: mdl-29482394

Assuntos

Isoquinolinas/farmacologia; Piperazinas/farmacologia; Inibidores da Agregação Plaquetária/farmacologia; Receptores Adrenérgicos alfa 2/metabolismo; Relação Dose-Resposta a Droga; Humanos; Isoquinolinas/síntese química; Isoquinolinas/química; Modelos Moleculares; Estrutura Molecular; Piperazina; Piperazinas/síntese química; Piperazinas/química; Agregação Plaquetária/efeitos dos fármacos; Inibidores da Agregação Plaquetária/síntese química; Inibidores da Agregação Plaquetária/química; Testes de Função Plaquetária; Relação Estrutura-Atividade

Palavras-chave

ARC-239; Antiplatelet agents; alpha 2B receptor antagonists; blockade of the platelet aggregation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Inibidores da Agregação Plaquetária / Receptores Adrenérgicos alfa 2 / Isoquinolinas Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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