Identification of a highly neurotoxic &#945;-synuclein species inducing mitochondrial damage and mitophagy in Parkinson's disease.

Grassi, Diego; Howard, Shannon; Zhou, Minghai; Diaz-Perez, Natalia; Urban, Nicolai T; Guerrero-Given, Debbie; Kamasawa, Naomi; Volpicelli-Daley, Laura A; LoGrasso, Philip; Lasmézas, Corinne Ida

Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson's disease.

Grassi, Diego; Howard, Shannon; Zhou, Minghai; Diaz-Perez, Natalia; Urban, Nicolai T; Guerrero-Given, Debbie; Kamasawa, Naomi; Volpicelli-Daley, Laura A; LoGrasso, Philip; Lasmézas, Corinne Ida.

Afiliação

Grassi D; Department of Immunology and Microbiology, Scripps Florida, The Scripps Research Institute, Jupiter, FL 33458.
Howard S; Department of Neuroscience, Scripps Florida, The Scripps Research Institute, Jupiter, FL 33458.
Zhou M; Department of Molecular Medicine Scripps Florida, The Scripps Research Institute, Jupiter, FL 33458.
Diaz-Perez N; Department of Immunology and Microbiology, Scripps Florida, The Scripps Research Institute, Jupiter, FL 33458.
Urban NT; Department of Neuroscience, Scripps Florida, The Scripps Research Institute, Jupiter, FL 33458.
Guerrero-Given D; Private address, Palm Beach Gardens, FL 33418.
Kamasawa N; Light Microscopy Facility, Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458.
Volpicelli-Daley LA; Electron Microscopy Facility, Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458.
LoGrasso P; Electron Microscopy Facility, Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458.
Lasmézas CI; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294.

Proc Natl Acad Sci U S A ; 115(11): E2634-E2643, 2018 03 13.

Article em En | MEDLINE | ID: mdl-29487216

Assuntos

Autofagia/efeitos dos fármacos; Mitofagia/efeitos dos fármacos; Neurotoxinas; Doença de Parkinson/metabolismo; alfa-Sinucleína; Acetil-CoA Carboxilase/química; Acetil-CoA Carboxilase/metabolismo; Animais; Encéfalo/efeitos dos fármacos; Encéfalo/patologia; Química Encefálica; Técnicas de Cultura de Células; Células Cultivadas; Humanos; Lisossomos/metabolismo; Camundongos; Mitocôndrias; Neurotoxinas/química; Neurotoxinas/metabolismo; Neurotoxinas/toxicidade; Estresse Oxidativo/efeitos dos fármacos; Fosforilação; alfa-Sinucleína/química; alfa-Sinucleína/metabolismo; alfa-Sinucleína/toxicidade

Palavras-chave

Parkinson's disease; alpha-synuclein; autophagy; mitochondria; toxicity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Autofagia / Alfa-Sinucleína / Mitofagia / Neurotoxinas Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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