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A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications.
He, Haihong; Xia, Yang; Qi, Yingxue; Wang, Hong-Yin; Wang, Zhuang; Bao, Jianming; Zhang, Ziqian; Wu, Fu-Gen; Wang, Haolu; Chen, Daijie; Yang, Dahai; Liang, Xiaowen; Chen, Jinquan; Zhou, Shengmin; Liang, Xin; Qian, Xuhong; Yang, Youjun.
Afiliação
  • He H; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, Shanghai Key Laboratory of New Drug Design, School of Pharmacy , East China University of Science and Technology , Shanghai , 200237 , China.
  • Xia Y; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, Shanghai Key Laboratory of New Drug Design, School of Pharmacy , East China University of Science and Technology , Shanghai , 200237 , China.
  • Qi Y; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, Shanghai Key Laboratory of New Drug Design, School of Pharmacy , East China University of Science and Technology , Shanghai , 200237 , China.
  • Wang HY; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering , Southeast University , Nanjing , Jiangsu 210096 , China.
  • Wang Z; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, Shanghai Key Laboratory of New Drug Design, School of Pharmacy , East China University of Science and Technology , Shanghai , 200237 , China.
  • Bao J; School of Life Science and Biopharmaceutics , Shenyang Pharmaceutical University , Shenyang , Liaoning 110016 , China.
  • Zhang Z; Guangxi Scientific Research Center of Traditional Chinese Medicine , Guangxi University of Chinese Medicine , Nanning , Guangxi 530200 , China.
  • Wu FG; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering , Southeast University , Nanjing , Jiangsu 210096 , China.
  • Wang H; Therapeutics Research Centre, The University of Queensland Diamantina Institute , The University of Queensland, Translational Research Institute , Woolloongabba , QLD 4102 , Australia.
  • Chen D; School of Pharmacy , Shanghai Jiao Tong University , Shanghai , 200240 , China.
  • Yang D; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, Shanghai Key Laboratory of New Drug Design, School of Pharmacy , East China University of Science and Technology , Shanghai , 200237 , China.
  • Liang X; Therapeutics Research Centre, The University of Queensland Diamantina Institute , The University of Queensland, Translational Research Institute , Woolloongabba , QLD 4102 , Australia.
  • Chen J; State Key Laboratory of Precision Spectroscopy , East China Normal University , Shanghai , 200062 , China.
  • Zhou S; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, Shanghai Key Laboratory of New Drug Design, School of Pharmacy , East China University of Science and Technology , Shanghai , 200237 , China.
  • Liang X; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, Shanghai Key Laboratory of New Drug Design, School of Pharmacy , East China University of Science and Technology , Shanghai , 200237 , China.
  • Qian X; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, Shanghai Key Laboratory of New Drug Design, School of Pharmacy , East China University of Science and Technology , Shanghai , 200237 , China.
  • Yang Y; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, Shanghai Key Laboratory of New Drug Design, School of Pharmacy , East China University of Science and Technology , Shanghai , 200237 , China.
Bioconjug Chem ; 29(4): 1194-1198, 2018 04 18.
Article em En | MEDLINE | ID: mdl-29498825
ABSTRACT
Nitric oxide (NO) is a versatile endogenous molecule, involved in various physiological processes and implicated in the progression of many pathological conditions. Therefore, NO donors are valuable tools in NO related basic and applied applications. The traditional spontaneous NO donors are limited in scenarios where flux, localization, and dose of NO could be monitored. This has promoted the development of novel NO donors, whose NO release is not only under control, but also self-calibrated. Herein, we reported a phototriggered and photocalibrated NO donor (NOD565) with an N-nitroso group on a rhodamine dye. NOD565 is nonfluorescent and could release NO efficiently upon irradiation by green light. A bright rhodamine dye is generated as a side-product and its fluorescence can be used to monitor the NO release. The potentials of NOD565 in practical applications are showcased in in vitro studies, e.g., platelet aggregation inhibition and fungi growth suppression.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Raios Ultravioleta / Doadores de Óxido Nítrico / Processos Fotoquímicos Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Raios Ultravioleta / Doadores de Óxido Nítrico / Processos Fotoquímicos Idioma: En Ano de publicação: 2018 Tipo de documento: Article