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A regulated multiscale closed-loop cardiovascular model, with applications to hemorrhage and hypertension.
Canuto, Daniel; Chong, Kwitae; Bowles, Cayley; Dutson, Erik P; Eldredge, Jeff D; Benharash, Peyman.
Afiliação
  • Canuto D; Mechanical and Aerospace Engineering Department, University of California, Los Angeles, California, USA.
  • Chong K; Mechanical and Aerospace Engineering Department, University of California, Los Angeles, California, USA.
  • Bowles C; Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
  • Dutson EP; Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
  • Eldredge JD; Center for Advanced Surgical and Interventional Technology, University of California, Los Angeles, California, USA.
  • Benharash P; Mechanical and Aerospace Engineering Department, University of California, Los Angeles, California, USA.
Int J Numer Method Biomed Eng ; 34(6): e2975, 2018 06.
Article em En | MEDLINE | ID: mdl-29500858
ABSTRACT
A computational tool is developed for simulating the dynamic response of the human cardiovascular system to various stressors and injuries. The tool couples 0-dimensional models of the heart, pulmonary vasculature, and peripheral vasculature to 1-dimensional models of the major systemic arteries. To simulate autonomic response, this multiscale circulatory model is integrated with a feedback model of the baroreflex, allowing control of heart rate, cardiac contractility, and peripheral impedance. The performance of the tool is demonstrated in 2 scenarios neurogenic hypertension by sustained stimulation of the sympathetic nervous system and an acute 10% hemorrhage from the left femoral artery.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artéria Femoral / Hemorragia / Hipertensão / Modelos Cardiovasculares Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artéria Femoral / Hemorragia / Hipertensão / Modelos Cardiovasculares Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article