In Vivo Expansion and Antitumor Activity of Coinfused CD28- and 4-1BB-Engineered CAR-T Cells in Patients with B Cell Leukemia.

Cheng, Zhi; Wei, Runhong; Ma, Qiuling; Shi, Lin; He, Feng; Shi, Zixiao; Jin, Tao; Xie, Ronglin; Wei, Baofeng; Chen, Jing; Fang, Hongliang; Han, Xiaolu; Rohrs, Jennifer A; Bryson, Paul; Liu, Yarong; Li, Qi-Jing; Zhu, Bo; Wang, Pin

In Vivo Expansion and Antitumor Activity of Coinfused CD28- and 4-1BB-Engineered CAR-T Cells in Patients with B Cell Leukemia.

Cheng, Zhi; Wei, Runhong; Ma, Qiuling; Shi, Lin; He, Feng; Shi, Zixiao; Jin, Tao; Xie, Ronglin; Wei, Baofeng; Chen, Jing; Fang, Hongliang; Han, Xiaolu; Rohrs, Jennifer A; Bryson, Paul; Liu, Yarong; Li, Qi-Jing; Zhu, Bo; Wang, Pin.

Afiliação

Cheng Z; Department of Hematology, The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China.
Wei R; Department of Hematology, The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China.
Ma Q; Department of Hematology, The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China.
Shi L; Department of Hematology, The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China.
He F; R&D Department, HRAIN Biotechnology Co., Ltd., Shanghai, China.
Shi Z; R&D Department, HRAIN Biotechnology Co., Ltd., Shanghai, China.
Jin T; R&D Department, HRAIN Biotechnology Co., Ltd., Shanghai, China.
Xie R; R&D Department, HRAIN Biotechnology Co., Ltd., Shanghai, China.
Wei B; R&D Department, HRAIN Biotechnology Co., Ltd., Shanghai, China.
Chen J; R&D Department, HRAIN Biotechnology Co., Ltd., Shanghai, China.
Fang H; R&D Department, HRAIN Biotechnology Co., Ltd., Shanghai, China.
Han X; Department of Genetic, Molecular & Cellular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Rohrs JA; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Bryson P; Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA, USA.
Liu Y; R&D Department, HRAIN Biotechnology Co., Ltd., Shanghai, China.
Li QJ; Department of Immunology, Duke University Medical Center, Durham, NC, USA.
Zhu B; Institute of Cancer, Xinqiao Hospital, The Third Military Medical University, Chongqing, China. Electronic address: b.davis.zhu@gmail.com.
Wang P; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA; Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA, USA; Department of Pharmaceutical Sciences and Pharmacology, University of Southern California,

Mol Ther ; 26(4): 976-985, 2018 04 04.

Article em En | MEDLINE | ID: mdl-29503204

Assuntos

Antígenos CD28/imunologia; Imunoterapia Adotiva; Leucemia Linfocítica Crônica de Células B/imunologia; Leucemia Linfocítica Crônica de Células B/terapia; Receptores de Antígenos de Linfócitos T/metabolismo; Receptores de Antígenos Quiméricos/metabolismo; Linfócitos T/imunologia; Linfócitos T/metabolismo; Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral/imunologia; Adolescente; Adulto; Idoso; Animais; Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos; Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico; Antígenos CD28/metabolismo; Criança; Pré-Escolar; Terapia Combinada; Modelos Animais de Doenças; Feminino; Vetores Genéticos/genética; Humanos; Imunoterapia Adotiva/efeitos adversos; Imunoterapia Adotiva/métodos; Leucemia Linfocítica Crônica de Células B/genética; Leucemia Linfocítica Crônica de Células B/metabolismo; Masculino; Camundongos Transgênicos; Pessoa de Meia-Idade; Receptores de Antígenos de Linfócitos T/genética; Receptores de Antígenos Quiméricos/genética; Retroviridae/genética; Resultado do Tratamento; Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto; Adulto Jovem

Palavras-chave

4-1BB signaling domain; CD28 signaling domain; chimeric antigen receptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Antígenos de Linfócitos T / Linfócitos T / Leucemia Linfocítica Crônica de Células B / Imunoterapia Adotiva / Antígenos CD28 / Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral / Receptores de Antígenos Quiméricos Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Aged / Animals / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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