Histone deacetylase inhibitor chidamide induces growth inhibition and apoptosis in NK/T lymphoma cells through ATM-Chk2-p53-p21 signalling pathway.

Zhou, Jianan; Zhang, Canjing; Sui, Xianxian; Cao, Shengxuan; Tang, Feng; Sun, Shuhui; Wang, Songmei; Chen, Bobin

Histone deacetylase inhibitor chidamide induces growth inhibition and apoptosis in NK/T lymphoma cells through ATM-Chk2-p53-p21 signalling pathway.

Zhou, Jianan; Zhang, Canjing; Sui, Xianxian; Cao, Shengxuan; Tang, Feng; Sun, Shuhui; Wang, Songmei; Chen, Bobin.

Afiliação

Zhou J; Department of Hematology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Urumqi Middle Road, Shanghai, 200040, China.
Zhang C; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Sui X; Laboratory of Medical Molecular Biology, Experimental Teaching Center, School of Basic Medical Sciences, Fudan University, Dongan Road, Shanghai, 200032, China.
Cao S; Shanghai Medical College, Fudan University, Shanghai, China.
Tang F; Department of Pathology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Sun S; Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Wang S; Laboratory of Medical Molecular Biology, Experimental Teaching Center, School of Basic Medical Sciences, Fudan University, Dongan Road, Shanghai, 200032, China. smwang2@fudan.edu.cn.
Chen B; Department of Hematology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Urumqi Middle Road, Shanghai, 200040, China. bbchen@fudan.edu.cn.

Invest New Drugs ; 36(4): 571-580, 2018 08.

Article em En | MEDLINE | ID: mdl-29504068

Assuntos

Aminopiridinas/farmacologia; Apoptose/efeitos dos fármacos; Benzamidas/farmacologia; Proliferação de Células/efeitos dos fármacos; Inibidores de Histona Desacetilases/farmacologia; Células Matadoras Naturais/efeitos dos fármacos; Linfoma/tratamento farmacológico; Transdução de Sinais/efeitos dos fármacos; Proteínas Mutadas de Ataxia Telangiectasia/metabolismo; Linhagem Celular Tumoral; Quinase do Ponto de Checagem 2/metabolismo; Inibidor de Quinase Dependente de Ciclina p21/metabolismo; Fase G1/efeitos dos fármacos; Humanos; Células Matadoras Naturais/metabolismo; Linfoma/metabolismo; Fase de Repouso do Ciclo Celular/efeitos dos fármacos; Proteína Supressora de Tumor p53/metabolismo

Palavras-chave

Cell cycle checkpoint pathway; Chidamide; DNA damage response; NK/T cell lymphoma

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzamidas / Células Matadoras Naturais / Transdução de Sinais / Apoptose / Proliferação de Células / Inibidores de Histona Desacetilases / Aminopiridinas / Linfoma Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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