Second-harmonic imaging microscopy for identifying colorectal intraepithelial neoplasia.
J Microsc
; 271(1): 31-35, 2018 07.
Article
em En
| MEDLINE
| ID: mdl-29505679
ABSTRACT
In this study, second-harmonic imaging microscopy was used to monitor precancerous colorectal lesions at different stages. It was found that the morphology of glands and lamina propria in mucosa changes with the progression of colorectal diseases from normal to low-grade intraepithelial neoplasia to high-grade intraepithelial neoplasia and this microscopy has the ability of direct visualization of these warning symptoms. Furthermore, two morphologic variables were quantified to determine the changes of glands and collagen in lamina propria during the development of colorectal intraepithelial neoplasia. These results suggest that second-harmonic imaging microscopy has the potential in label-freely and effectively distinguishing between normal and precancerous colorectal tissues, and will be helpful for early diagnosis and treatment of colorectal diseases.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carcinoma in Situ
/
Neoplasias Colorretais
/
Microscopia
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
/
Screening_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article