Blocking the ART2.2/P2X7-system is essential to avoid a detrimental bias in functional CD4 T cell studies.
Eur J Immunol
; 48(6): 1078-1081, 2018 06.
Article
em En
| MEDLINE
| ID: mdl-29508376
Murine T cell subsets differ in their expression level of P2X7. Depending on several parameters like extracellular NAD+ , P2X7 can be ADP-ribosylated rapidly by adjacent ARTC2.2 resulting in susceptibilities to apoptosis to a varying extent. This detrimental effect can be prevented when drugs like KN-62 are present during cell preparations.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
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Subpopulações de Linfócitos T
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ADP Ribose Transferases
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Transporte de Íons
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Receptores Purinérgicos P2X7
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article