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Neurocognitive impairment with hepatitis C and HIV co-infection in Southern Brazil.
de Almeida, Sérgio Monteiro; de Pereira, Ana Paula; Pedroso, Maria Lucia Alves; Ribeiro, Clea E; Rotta, Indianara; Tang, Bin; Umlauf, Anya; Franklin, Donald; Saloner, Rowan G; Batista, Maria Geny Ribas; Letendre, Scott; Heaton, Robert K; Ellis, Ronald J; Cherner, Mariana.
Afiliação
  • de Almeida SM; Hospital de Clínicas-UFPR, Universidade Federal do Paraná, Seção de Virologia, Setor Análises Clínicas, Rua Padre Camargo, 280, Curitiba, PR, 80060-240, Brazil. sergio.ma@ufpr.br.
  • de Pereira AP; Faculdades Pequeno Príncipe, Curitiba, Paraná, Brazil. sergio.ma@ufpr.br.
  • Pedroso MLA; Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Paraná, Brazil. sergio.ma@ufpr.br.
  • Ribeiro CE; Hospital de Clínicas-UFPR, Universidade Federal do Paraná, Seção de Virologia, Setor Análises Clínicas, Rua Padre Camargo, 280, Curitiba, PR, 80060-240, Brazil.
  • Rotta I; Hospital de Clínicas-UFPR, Universidade Federal do Paraná, Seção de Virologia, Setor Análises Clínicas, Rua Padre Camargo, 280, Curitiba, PR, 80060-240, Brazil.
  • Tang B; Hospital de Clínicas-UFPR, Universidade Federal do Paraná, Seção de Virologia, Setor Análises Clínicas, Rua Padre Camargo, 280, Curitiba, PR, 80060-240, Brazil.
  • Umlauf A; Hospital de Clínicas-UFPR, Universidade Federal do Paraná, Seção de Virologia, Setor Análises Clínicas, Rua Padre Camargo, 280, Curitiba, PR, 80060-240, Brazil.
  • Franklin D; Faculdades Pequeno Príncipe, Curitiba, Paraná, Brazil.
  • Saloner RG; Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Paraná, Brazil.
  • Batista MGR; University of California San Diego, San Diego, CA, USA.
  • Letendre S; University of California San Diego, San Diego, CA, USA.
  • Heaton RK; University of California San Diego, San Diego, CA, USA.
  • Ellis RJ; University of California San Diego, San Diego, CA, USA.
  • Cherner M; Hospital de Clínicas-UFPR, Universidade Federal do Paraná, Seção de Virologia, Setor Análises Clínicas, Rua Padre Camargo, 280, Curitiba, PR, 80060-240, Brazil.
J Neurovirol ; 24(3): 339-349, 2018 06.
Article em En | MEDLINE | ID: mdl-29516346
ABSTRACT
Although cognitive impairment has been well documented in human immunodeficiency virus (HIV) and hepatitis C virus (HCV) mono-infections, research on neurocognitive effects is limited in the context of HIV/HCV co-infection. The aims of this study were to explore the interplay between HIV and HCV infections in the expression of neurocognitive impairment (NCI), and to examine the differences in test performance between HIV/HCV co-infected and HIV or HCV mono-infected patients. A total of 128 participants from Southern Brazil underwent a comprehensive neuropsychological (NP) battery comprising 18 tests. Participants were grouped according to their serological status HCV mono-infected (n = 20), HIV mono-infected (n = 48), HIV/HCV co-infected (n = 12), and HIV-/HCV-uninfected controls (n = 48). The frequencies of HIV subtypes B and C between the HIV mono-infected and HIV/HCV co-infected groups were comparable. There was greater prevalence of neuropsychological impairment among all three infection groups compared with the uninfected control group, but no statistically significant differences among mono- and co-infected groups were found. HCV infection was associated with cognitive deficits, independently of liver dysfunction. HCV infection did not show an additive effect on neurocognitive function among HIV+. NCI was independent of HCV RNA on peripheral blood, CSF, and hepatic injury. While we did not find additive global effect, in the present study, there was some evidence of additive HIV/HCV co-infection effects in speed of information processing, executive function, and verbal fluency domains when comparing the co-infected group with the other three groups. NP impairment was not dependent on HCV subtypes.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV / Cognição / Hepacivirus / Hepatite C Crônica / Função Executiva / Disfunção Cognitiva Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País como assunto: America do sul / Brasil Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV / Cognição / Hepacivirus / Hepatite C Crônica / Função Executiva / Disfunção Cognitiva Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País como assunto: America do sul / Brasil Idioma: En Ano de publicação: 2018 Tipo de documento: Article