Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone.

Perron, Amelie; Nishikawa, Yoshihiro; Iwata, Jun; Shimojo, Hiromi; Takaya, Junichiro; Kobayashi, Kumiko; Imayoshi, Itaru; Mbenza, Naasson M; Takenoya, Mihoko; Kageyama, Ryoichiro; Kodama, Yuzo; Uesugi, Motonari

Perron, Amelie; Nishikawa, Yoshihiro; Iwata, Jun; Shimojo, Hiromi; Takaya, Junichiro; Kobayashi, Kumiko; Imayoshi, Itaru; Mbenza, Naasson M; Takenoya, Mihoko; Kageyama, Ryoichiro; Kodama, Yuzo; Uesugi, Motonari.

Afiliação

Perron A; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Uji, Kyoto 611-0011.
Nishikawa Y; Department of Gastroenterology and Hepatology, Graduate School of Medicine.
Iwata J; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011.
Shimojo H; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Uji, Kyoto 611-0011; Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Takaya J; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011.
Kobayashi K; Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Imayoshi I; Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan; Graduate School of Biostudies, Kyoto University, Kyoto 606-8507, Japan.
Mbenza NM; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011.
Takenoya M; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Uji, Kyoto 611-0011.
Kageyama R; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Uji, Kyoto 611-0011; Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Kodama Y; Department of Gastroenterology and Hepatology, Graduate School of Medicine. Electronic address: kodamayu@kuhp.kyoto-u.ac.jp.
Uesugi M; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Uji, Kyoto 611-0011. Electronic address: uesugi@scl.kyoto-u.ac.jp.

J Biol Chem ; 293(21): 8285-8294, 2018 05 25.

Article em En | MEDLINE | ID: mdl-29523683

Assuntos

Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Ensaios de Triagem em Larga Escala; Neoplasias Pancreáticas/tratamento farmacológico; Proteínas Repressoras/antagonistas & inibidores; Bibliotecas de Moléculas Pequenas/farmacologia; Fatores de Transcrição HES-1/antagonistas & inibidores; Animais; Antineoplásicos/química; Ciclo Celular; Diferenciação Celular; Proliferação de Células; Feminino; Humanos; Camundongos; Camundongos Nus; Neoplasias Pancreáticas/metabolismo; Neoplasias Pancreáticas/patologia; Proibitinas; Proteínas Repressoras/genética; Proteínas Repressoras/metabolismo; Fatores de Transcrição HES-1/genética; Fatores de Transcrição HES-1/metabolismo; Transcrição Gênica; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Notch pathway; Prohibitin 2; basic helix-loop-helix transcription factor; cell proliferation; chaperone; chemical biology; pancreatic cancer; small molecule

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Proteínas Repressoras / Apoptose / Bibliotecas de Moléculas Pequenas / Ensaios de Triagem em Larga Escala / Fatores de Transcrição HES-1 / Antineoplásicos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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