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Design, synthesis and biological activity of 4-(4-benzyloxy)phenoxypiperidines as selective and reversible LSD1 inhibitors.
Xi, Jiayue; Xu, Siyuan; Zhang, Lulu; Bi, Xueyuan; Ren, Yanshen; Liu, Yu-Chih; Gu, Yueqing; Xu, Yungen; Lan, Fei; Zha, Xiaoming.
Afiliação
  • Xi J; Department of Pharmaceutical Engineering & Department of Biochemical Engineering, 639 Longmian Avenue, Nanjing 211198, PR China; Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China.
  • Xu S; Laboratory of Epigenetics, Institute of Biochemical Sciences, Fudan University, 131 Dong'An Road, Shanghai 200032, PR China.
  • Zhang L; Department of Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, PR China.
  • Bi X; Department of Pharmaceutical Engineering & Department of Biochemical Engineering, 639 Longmian Avenue, Nanjing 211198, PR China.
  • Ren Y; Department of Pharmaceutical Engineering & Department of Biochemical Engineering, 639 Longmian Avenue, Nanjing 211198, PR China.
  • Liu YC; Shanghai ChemPartner Co., Ltd., Zhangjiang Hi-Tech Park, Shanghai 201203, PR China.
  • Gu Y; Department of Pharmaceutical Engineering & Department of Biochemical Engineering, 639 Longmian Avenue, Nanjing 211198, PR China.
  • Xu Y; Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China.
  • Lan F; Laboratory of Epigenetics, Institute of Biochemical Sciences, Fudan University, 131 Dong'An Road, Shanghai 200032, PR China. Electronic address: fei_lan@fudan.edu.cn.
  • Zha X; Department of Pharmaceutical Engineering & Department of Biochemical Engineering, 639 Longmian Avenue, Nanjing 211198, PR China. Electronic address: xmzha@cpu.edu.cn.
Bioorg Chem ; 78: 7-16, 2018 08.
Article em En | MEDLINE | ID: mdl-29524666
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Desenho de Fármacos / Inibidores Enzimáticos / Histona Desmetilases / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Desenho de Fármacos / Inibidores Enzimáticos / Histona Desmetilases / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article