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Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.
Reich, Siegfried H; Sprengeler, Paul A; Chiang, Gary G; Appleman, James R; Chen, Joan; Clarine, Jeff; Eam, Boreth; Ernst, Justin T; Han, Qing; Goel, Vikas K; Han, Edward Z R; Huang, Vera; Hung, Ivy N J; Jemison, Adrianna; Jessen, Katti A; Molter, Jolene; Murphy, Douglas; Neal, Melissa; Parker, Gregory S; Shaghafi, Michael; Sperry, Samuel; Staunton, Jocelyn; Stumpf, Craig R; Thompson, Peggy A; Tran, Chinh; Webber, Stephen E; Wegerski, Christopher J; Zheng, Hong; Webster, Kevin R.
Afiliação
  • Reich SH; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
  • Sprengeler PA; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
  • Chiang GG; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
  • Appleman JR; Primmune Therapeutics, Inc. , 3210 Merryfield Row , San Diego , California 92121 , United States.
  • Chen J; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
  • Clarine J; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
  • Eam B; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
  • Ernst JT; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
  • Han Q; Structure-Based Design, Inc. , 6048 Cornerstone Court West #D , San Diego , California 92121 , United States.
  • Goel VK; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
  • Han EZR; Structure-Based Design, Inc. , 6048 Cornerstone Court West #D , San Diego , California 92121 , United States.
  • Huang V; Molecular Stethoscope , 10835 Road to the Cure #100 , San Diego , California 92121 , United States.
  • Hung INJ; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
  • Jemison A; Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104 , United States.
  • Jessen KA; Oncternal Therapeutics , 3525 Del Mar Heights Road #821 , San Diego , California 92130 , United States.
  • Molter J; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
  • Murphy D; Molcentrics, Inc. , 11835 Carmel Mountain Road #1304-110 , San Diego , California 92128 , United States.
  • Neal M; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
  • Parker GS; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
  • Shaghafi M; Abide Therapeutics , 10835 Road to the Cure, Suite 250 , San Diego , California 92121 , United States.
  • Sperry S; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
  • Staunton J; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
  • Stumpf CR; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
  • Thompson PA; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
  • Tran C; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
  • Webber SE; Polaris Pharmaceuticals , 9373 Towne Centre Drive #150 , San Diego , California 92121 , United States.
  • Wegerski CJ; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
  • Zheng H; Structure-Based Design, Inc. , 6048 Cornerstone Court West #D , San Diego , California 92121 , United States.
  • Webster KR; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.
J Med Chem ; 61(8): 3516-3540, 2018 04 26.
Article em En | MEDLINE | ID: mdl-29526098
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Piridonas / Pirimidinas / Compostos de Espiro / Proteínas Serina-Treonina Quinases / Peptídeos e Proteínas de Sinalização Intracelular / Inibidores de Proteínas Quinases / Antineoplásicos Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Piridonas / Pirimidinas / Compostos de Espiro / Proteínas Serina-Treonina Quinases / Peptídeos e Proteínas de Sinalização Intracelular / Inibidores de Proteínas Quinases / Antineoplásicos Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2018 Tipo de documento: Article