Stapled, Long-Acting Glucagon-like Peptide 2 Analog with Efficacy in Dextran Sodium Sulfate Induced Mouse Colitis Models.
J Med Chem
; 61(7): 3218-3223, 2018 04 12.
Article
em En
| MEDLINE
| ID: mdl-29528634
ABSTRACT
Glucagon-like peptide 2 (GLP-2) is a hormone that has been shown to stimulate intestinal growth and attenuate intestinal inflammation. Despite being efficacious in a variety of animal models of disease, its therapeutic potential is hampered by the short half-life in vivo. We now describe a highly potent, stapled long-acting GLP-2 analog, peptide 10, that has a more than 10-fold longer half-life than teduglutide and improved intestinotrophic and anti-inflammatory effects in mouse models of DSS-induced colitis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fármacos Gastrointestinais
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Anti-Inflamatórios não Esteroides
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Colite
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Peptídeo 2 Semelhante ao Glucagon
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article