[Second Austrian consensus on the safe use of anti-TNFα-antibodies in patients with inflammatory bowel diseases]. / Zweiter österreichischer Konsensus zur sicheren Anwendung von anti-TNF-α-Antikörpern bei chronisch-entzündlichen Darmerkrankungen.
Z Gastroenterol
; 56(3): 275-302, 2018 03.
Article
em De
| MEDLINE
| ID: mdl-29529682
ABSTRACT
Anti-TNFα-antibodies have revolutionized the therapy of inflammatory bowel diseases and other immune-mediated inflammatory diseases. Due to the increasing application of these substances, the Working Group of Inflammatory Bowel Diseases of the Austrian Association of Gastroenterology and Hepatology intended to update their consensus report on the safe use of Infliximab (published in 2010) and to enlarge its scope to cover all anti-TNFα-antibodies. The present consensus report summarizes the current evidence on the safe use of anti-TNFα-antibodies and covers the following topics general risk of infection, bacterial infections (i.âe., Clostridium difficile, Tuberculosis, food hygiene), Pneumocystis jiroveci, viral infections (i.âe., Hepatitis B, Hepatitis C, HIV, CMV, VZV), vaccination in general and recommendation for vaccines, gastrointestinal aspects (i.âe., perianal fistula, abdominal fistula, intestinal strictures, stenosis and bowel obstruction), dermatologic aspects (skin malignancies, eczema-like drug-related skin eruption), infusion reactions and immunogenicity, demyelinating diseases, hepatotoxicity, haematotoxicity, congestive heart failure, risk and history of malignancies, and pregnancy and breast feeding. For practical reasons, the relevant aspects are summarized in a checklist which is divided into two parts issues to be addressed before therapy and issues to be addressed during therapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fármacos Gastrointestinais
/
Doenças Inflamatórias Intestinais
/
Fator de Necrose Tumoral alfa
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Infliximab
/
Anticorpos Monoclonais
Tipo de estudo:
Guideline
Limite:
Female
/
Humans
/
Pregnancy
País como assunto:
Europa
Idioma:
De
Ano de publicação:
2018
Tipo de documento:
Article