[Expression of TOPK/PBK in children with malignant lymphoma or reactive lymphoid hyperplasia].
Zhongguo Dang Dai Er Ke Za Zhi
; 20(3): 214-217, 2018 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-29530122
ABSTRACT
OBJECTIVE:
To study the difference in expression of TOPK/PBK in lymph nodes between children with malignant lymphoma and those with reactive lymphoid hyperplasia.METHODS:
Eighty children with malignant lymphoma and twenty children with reactive lymphoid hyperplasia were enrolled as subjects. Immunohistochemistry was used to determine the expression of TOPK/PBK in all the subjects. The expression of TOPK/PBK was compared between the two groups.RESULTS:
The TOPK/PBK-positivity rate was significantly higher in children with malignant lymphoma than in those with reactive lymphoid hyperplasia (P<0.05). There was no significant difference in the TOPK/PBK-positivity rate between the children with Hodgkin's lymphoma and non-Hodgkin's lymphoma (NHL). There were significant differences in the TOPK/PBK-positivity rate among children with different pathological types of NHL (P<0.05) the children with lymphoblastic lymphoma showed the highest TOPK/PBK-positivity rate and those with mature B-cell lymphoma and mature T/NK-cell lymphoma had a similar TOPK/PBK-positivity rate.CONCLUSIONS:
The expression of TOPK/PBK is up-regulated in the lymph nodes of children with malignant lymphoma. The expression level of TOPK/PBK may be related to the pathological type of NHL.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pseudolinfoma
/
Quinases de Proteína Quinase Ativadas por Mitógeno
/
Linfoma
Limite:
Adolescent
/
Child
/
Child, preschool
/
Humans
/
Infant
/
Newborn
Idioma:
Zh
Ano de publicação:
2018
Tipo de documento:
Article