Guidelines for prophylaxis of Pneumocystis pneumonia cannot rely solely on CD4-cell count in autoimmune and inflammatory diseases.
Clin Exp Rheumatol
; 36(3): 490-493, 2018.
Article
em En
| MEDLINE
| ID: mdl-29533748
ABSTRACT
OBJECTIVES:
Guidelines for preventing Pneumocystis pneumonia (PCP) in HIV patients are based on CD4 below 200/mm3. Such cut-off value is suggested to guide prophylaxis in non-HIV conditions (NHIV) especially in autoimmune and inflammatory diseases (AD). We aimed to determine if CD4 could be used to guide PCP prophylaxis in AD.METHODS:
CD4 and lymphocyte-count were retrospectively studied in patients diagnosed with PCP between January 2013 and February 2016.RESULTS:
129 patients were included. The median CD4-count was 302/mm3 in AD, which was significantly higher than in HIV patients (19/mm3; p<0.0001). Fifty percent (n=10) of AD patients had CD4 counts greater than 300/mm3.CONCLUSIONS:
Prophylaxis for PCP cannot rely solely on CD4-count in NHIV patients especially in AD.
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Base de dados:
MEDLINE
Assunto principal:
Pneumonia por Pneumocystis
/
Doenças Autoimunes
/
Linfócitos T CD4-Positivos
/
Infecções por HIV
/
Imunossupressores
/
Linfopenia
Tipo de estudo:
Etiology_studies
/
Guideline
/
Observational_studies
/
Risk_factors_studies
Limite:
Aged80
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article